Three people have died, four are fighting for life and dozens more have been injured following a horrific crash in North Queensland.

A bus collided with a car towing a caravan along the Bruce Highway near the Wilson Creek Rest Area, between Gumlu and Wangaratta, at 12.50pm on Sunday.

Some 33 people were on the inter-city bus travelling between Bowen and Townsville. Two people were in the car that was towing the caravan.

The force of the crash left the bus resting on train tracks with emergency services racing to the scene. 

Queensland Ambulance Service confirmed multiple people are being treated with at least 24 passengers suffering minor injuries.

A triage system has been set up due to the number of victims.

A Queensland Government Air rescue helicopter and a RACQ Helicopter Rescue Service were sent to the scene. Three Royal Flying Doctor Service planes are on standby.

Some of the passengers on the bus had been trapped in the wreckage, the Courier Mail reported.

Three people have died, four are fighting for life and dozens more have been injured following a horrific crash in North Queensland

The Queensland Ambulance Service confirmed multiple people are being treated for a range of injuries at the scene

Six of the injured passengers have been transported to Ayr Hospital and one flown to Townsville University Hospital. 

The bus driver is understood to have escaped with minor head injuries while two occupants were unharmed. 

A QAS spokesman described the scene as chaotic and challenging. 

‘Paramedics are on scene assessing several people with life-threatening injuries following reports of a two-vehicle crash involving a bus on the Bruce Highway north of Bowen,’ he said.

‘Motorists are advised the Bruce Highway is closed in both directions, and to expect long delays.’

Motorists travelling between Ayr and Bowen are being urged to avoid the area or expect long delays. 

The Forensic Crash Unit is investigating.

Daily Mail Australia contacted QAS for comment. 

More to come 

Six of the injured passengers have been transported to Ayr Hospital and one flown to Townsville University Hospital